Beneficial Effect of Successful Simultaneous Pancreas-Kidney Transplantation on Plasma Profile of Metalloproteinases in Type 1 Diabetes Mellitus Patients

It is not fully elucidated whether the restoring of normal glucose metabolism after successful simultaneous pancreas-kidney transplantation (SPK) improves vascular wall morphology and function in type 1 diabetic (T1D) patients. Therefore, we compared arterial stiffness, assessed by pulse wave velocity (PWV), carotid intima-media thickness (IMT), biomarkers calcification T1D patients SPK or kidney alone (KTA). In 39 KTA adult similar age, PWV, IMT, circulating matrix metalloproteinases (MMPs) were at median 83 months post transplantation. Additionally, plaques visualized semi-qualitatively classified. Although PWV IMT values similar, occurrence atherosclerotic (51.3 vs. 70.3%, p < 0.01) calcified lesions (35.9 64.9%, 0.05) was lower There significantly concentrations MMP-1, MMP-2, MMP-3, osteocalcin subjects. Among analyzed biomarkers, only logMMP-1, logMMP-2, logMMP-3 associated with log HbA1c. Multivariate stepwise backward regression analysis revealed that MMP-1 MMP-3 variability explained Normal achieved followed favorable profile metalloproteinases, which may reflect vasoprotective effect pancreas